The study was presented at United European Gastroenterology (UEG) Week 2024, billed as “The best gastroenterology congress in the world,” and published in the journal Advanced Science.

“For years, researchers have studied fat metabolism, but finding an effective way to block fat absorption has been difficult,” said Dr Wentao Shao, from the School of Medicine at Tongji University, Shanghai, and one of the study’s authors. “While most strategies focus on reducing dietary fat intake, our approach targets the body’s fat absorption process directly.”

All Model 120/122 differential pressure gauges either conform to and/or are designed to the requirements of the following standards:

Mid west instrument 120sa 10 oomanual

Dial Types: 3-1/2″ & 4-1/2″ Round Uni-Directional Round Anodized Aluminum housing assembly housing assembly, Non-Indication differential pressure switches available. Seals & Diaphragm Materials: Neoprene, Teflon, Ethylene Propylene and Perfluoroelastomer Connections: 7/16″-20 Straight thread “O” ring port Other Options: Reversed high/low process connections, Oxygen Cleaning, Stainless Steel Tags and more… Electrical Switches: 1 & 2 switch std, Class 1 Div. 1 & Div 2, Explosion Proof

Despite years of study resulting in an understanding of how fat is metabolized in the body, identifying an effective way of inhibiting its absorption in the intestine has remained out of reach. However, a new study may have the answer: oral nanoparticles that work directly on the small intestine to reduce the production of an enzyme responsible for fat absorption.

Mid west instrument 120sa 10 ooreview

120-AA-00-OO 3000 P.S.I.G. Working pressure, aluminum body, adjusting screws & end plugs, stainless steel piston, ceramic magnet, Buna-N, seals, 2½” round dial, ¼” FNPT back connections, “engineered plastic” gauge, case with shatter-resistant acrylic lens. Accuracy ± 2% F.S.* (Ascending)

120-SA-00-OO 6000 P.S.I.G. Working pressure, 316L S.S. body, adjusting screws & end plugs, stainless steel piston, ceramic magnet, Buna-N seals, 2½” round dial, ¼” FNPT back connections, “engineered plastic” gauge case with shatter-resistant acrylic lens. Accuracy ± 2% F.S.* (Ascending)

Mid westBackflow Test Kit calibration

“One of the most exciting aspects of this therapy is its ability to target fat absorption in the intestines without affecting the liver,” said Professor Zhaoyan Jiang, also from Tongji University’s School of Medicine and the study’s co-corresponding author. “This is important because previous studies showed that blocking SOAT2 in the liver can lead to fat buildup there – a risk our treatment avoids by focusing only on intestinal SOAT2.”

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Mid-West differential

In 2022, 43% of adults worldwide were overweight. Of these, 16% were living with obesity. As many would already know, being overweight and obese increases the risk of type 2 diabetes, heart disease, and certain cancers.

The researchers will continue to test the effectiveness and safety of the nanotherapy in larger animal models before looking to test it in humans. If successful, the therapy has great potential.

The researchers used nanoparticles containing small interfering RNAs (siRNAs) that, when swallowed, are delivered to the small intestine. (siRNAs are renowned for regulating gene expression.) There, they reduced the expression of SOAT2 by enterocytes and, therefore, inhibited fat absorption. When the nanotherapy was tested on mice, even mice fed a high-fat diet absorbed less fat and avoided obesity.

DP Ranges: PSID, Bar, Kpa, Dual Scale Body Materials: Aluminum or 316L Stainless Steel Dial Types: 3-1/2″ & 4-1/2″ Round Uni-Directional Round Anodized Aluminum housing assembly Seals & Diaphragm Materials: Buna-N, Viton Carbon or Stainless Steel Pipe Mount Kit (Pipe Mount option not available for Model 122) (Pipe Mount option not available with C or D switch option) Liquid Fill or Maximum Follower Pointer (Can not combine Liquid Fill with Maximum Follower Pointer options) Wall Mount Kit (Not available with back connections) (Wall Mount option not available with C or D switch option) Connections: 120/122(1/4″FNPT) and 120(1/2″FNPT)

Midinstruments

The enzyme in question is Sterol O-acyltransferase 2 (SOAT2), which is encoded by the SOAT2 gene. Uniquely present in liver cells (hepatocytes) and absorptive cells in the intestinal lining (enterocytes), SOAT2 has been studied extensively in relation to its role in the development of atherosclerosis or plaque buildup in the arteries.

Previous studies have found that blocking SOAT2 in hepatocytes leads to liver fat accumulation. In the present study, the researchers’ intestine-specific approach avoided that risk.

Mid westBackflow

“We believe that this nanoparticle system represents a breakthrough in obesity management, offering a new solution that tackles both fat metabolism and diet-related weight gain, potentially ushering in a new era of more effective treatments,” Jiang said.

Mid-West Backflow Gauges are capable of performing all known test procedures including those recommended by: ABPA, ASSE, AWWA, CSA, FCCC and HR-USC, NEWWA and UF-TREEO

Mid-West differential pressure gauges are designed to measure pressure drop across Filters, Strainers, Separators, Valves, Pumps, Chillers, etc. as well as for local flow indication and control. Basic gauge function is to measure the difference in pressure between two points in a system, the differential pressure results are displayed on the gauge dial.

“This oral treatment offers several advantages,” Shao said. “It’s non-invasive, has low toxicity, and it has high potential for better patient compliance compared to current obesity treatments, which are often invasive or difficult to maintain. This makes it a promising alternative.”

The researchers were also able to identify the mechanism underlying the regulation of fat absorption by SOAT2. Inhibiting SOAT2 in the small intestine triggers the degradation of a protein responsible for transporting fat, CD36. The process triggers cellular stress, which causes the recruitment of an enzyme called E3 ligase RNF3, which enhances CD36 degradation.

Mid-West Piston Type: Model 120 ± 2% or Model 122 ± 5% Full Scale Accuracy. Piston type gauges are primarily designed for liquid applications. Differential Pressure is sensed by the movement of a precisely ground floating piston/magnet in a precision bore against a calibrated spring. Any variation in pressure on either side of the piston/magnet will cause the magnet to move proportionally to the change in differential pressure. A rotary pointer magnet located close to the internal magnet, but outside the pressure housing, follows the movement of the piston magnet and indicates differential pressure on the dial. Piston type DP gauges exhibit a slight amount of bypass as the fluid crosses from the high to the low pressure port. Due to precision sizing of piston and body bore, leakage across the piston will not exceed 15 SCFH air at 100 PSID at ambient conditions.

A new oral nanotherapy works directly on the small intestine, reducing its ability to absorb fat from the food we eat, according to a new study. While the therapy is at the early stages, if it proves effective in humans, it has huge potential as a treatment for diet-related obesity.